Mireya Plass
Group Leader, Regenerative Medicine Program of IDIBELL
Group Leader of P-CMRC
Ramón y Cajal Principal Investigator
Dr. Mireya Plass studied a BS in Biology (2005) and holds a PhD in Health and Life Sciences (2011) from Pompeu Fabra University (Barcelona, Spain). She pursued postdoctoral training abroad first at the University of Copenhagen (Krogh Lab, 2011-2015) and later at the Berlin Institute for Medical Systems Biology (N. Rajewsky Lab, 2016-2019) before returning to Spain to complete her post-doctoral training at the Center for Genomic Regulation with a Marie Sklodowska-Curie Fellowship (Irimia Lab, 2019). In 2019, she joined the CMRB (now P-CMRC) as independent group leader and shortly after she was awarded a Ramón y Cajal contract from MINECO to support her position as principal investigator. Throughout her career, Dr. Plass has been interested in understanding how post-transcriptional regulatory mechanisms, such as splicing and alternative polyadenylation, shape gene expression from an evolutionary and systems biology perspective. Recently, her work has pioneered the use of single-cell transcriptomics to understand how gene expression drives cellular differentiation. As independent group leader, she wants to investigate the function of post-transcriptional regulation in gene expression and cell differentiation, and in particular its contribution to the developm ent of neurodevelopmental and neurodegenerative diseases.
Dr. Ana Gutiérrez Franco holds a BSc in Biotechnology by Universitat Autònoma de Barcelona (2010) and MS in Neuroscience (2011). During her PhD at Vall d’Hebron Research Institute (Dr. Carmen Espejo and Dr. Xavier Montalbán, 2010-2014) she studied the role of Semaphorin 3A and 7A in the neuroregulation and immunomodulation in multiple sclerosis. She performed a short stay of three months at the Center of Clinical Brain Sciences at the University of Edinburgh to study the role of TNF-alpha in iPSC cells derived from ALS patients and differentiated to oligodendrocytes. Her first postdoc at Institute Germans Trias i Pujol was focused on the evaluation of experimental treatments in a mouse model of Sanfilippo syndrome targeting autophagy mechanisms (Dr. A. Matilla, 2015). After that, she joined the Evolutionary Genomic lab led by Prof. Fyodor Kondrashov at the Center of Genomic Regulation as a post-doctoral scientist to study the potential compensatory mechanism of Lamp2A over a Parkinson’s disease causative mutation in alpha-synuclein (2016). In 2017, the group moved to the Institute of Science and Technology in Vienna. There, she combined her research on alpha-synuclein and Lamp2A interaction, with managerial duties as she was in charge of the experimental lab and supervision of students and technicians. During these years she has acquired expertise in cell culture techniques and neurodegenerative mice model handling and deep knowledge of immunomodulation, autophagy, and neurodegeneration. For the past three years, she has also been the Lab Manager of an annual summer school program (School of Molecular and Theoretical Biology) that merges real science projects with highly motivated and talented high school students from around the world. She joined the P-CMR[C] in June of 2020 as a Research Assistant in Mireya Plass’ group to study the influence of alternative polyadenylation in neuronal differentiation and the development of neurodegenerative diseases.
Franz obtained his BSc (2016) in Biology (Biology/Biochemistry – option Bioinformatics) and a MSc in Bioinformatics (2019), realised at University of PARIS – Sorbonne Cité USPC, where he got during his formation, courses and skills in several Bioinformatics areas (mainly Structural, Omics, Stats & Programming). As part of his MSc courses, he got the opportunity to realise several internships. First, in the National Center of Scientific Research (CNRS) Lab in Paris, with the team Post-transcriptional and Epigenetic regulation (PTER) about the implementation of unsupervised Machine Learning approaches for selection of co-translated mRNAs under the supervision of Prof C. BOUYIOKOS, and after, a second internship at the Hydraulic & Environmental National Laboratory Department (LNHE – Electricite de France EDF) in Paris about Legionella Pneumophila biotics and abiotics interaction and proliferation problematics inside Nuclear cooling Circuit. After the end of his academical course, he worked mainly on Metagenomics applications. Firstly, he worked in the same group as his last internship as bioinformatic engineer on L. Pneumophila problematic (EDF-Lab / LNHE). Secondly, he worked as a computational biologist at the National Research Institute INRAe-Transfert (INRAE) based in the sequencing genetic platform GET in Toulouse, about post-sequencing bioinformatic and biostatistical data analyses. Franz joined the Dr Mireya PLASS’ group for his PhD on Single-cell transcriptomic analyses for understanding RBPs contribution to cell differentiation, and how the transcriptomic networks regulated by these RBPs are altered in the development of neurodegenerative disease.
Marcel Schilling studied Bioinformatics (BSc & MSc) at the Free University Berlin working as a research assistant at the Max Planck Institute for Molecular Genetics. There, he computationally predicted the effects of single nucleotide polymorphisms on microRNA-targeting in the context of neuropsychiatric diseases. After completing his MSc studies, he joined the N. Rajewsky lab at the Berlin Institute for Medical Systems Biology as a PhD student. After working on a project developing a method to recover miRNA-target interactions from sRNA-seq data based on chimeric reads, he gained experience in the developing field of circular RNAs. For his PhD project, he developed a 3-dimensional physical model of the C. elegans gonad and a computational pipeline to map spatially resolved RNA-seq data onto it. He used the resulting virtual in-situ hybridization assays to investigate post-transcriptional regulation throughout the germline development from stem cells to mature oocytes. Before joining the Gene Regulation of Cell Identity lab at P-CMR[C], he investigated differential expression in Alzheimer´s patients brains at the Lübeck Interdisciplinary Platform for Genome Analytics at the Universität zu Lübeck.
Akshay J Ganesh graduated from the BSMS Dual Degree (Integrated Masters in Science) program at the Indian Institute of Science Education and Research, Thiruvananthapuram, with a Major in Biology and a Minor in Physics. During an internship at the Rajiv Gandhi Centre for Biotechnology, primarily involving identification of Antibiotic Resistance Genes (ARGs) in bacterial metagenomes, he got to appreciate how powerful computational methods can be in addressing biological questions. His master’s dissertation project was focused on analysing RNASeq data to identify the molecular regulators that guide the functioning of hematopoietic stem cells in mouse fetal liver. This project motivated him to study gene regulatory networks further and how disruptions in such mechanisms could result in disease manifestations like cancer and neurodegenerative disorders. He joined the Gene Regulation of Cell Identity Group under Dr. Mireya Plass as Bioinformatics Technician to help understand the gene regulatory cascades involved in the onset of Alzheimer’s Disease.
Nadia Jamshaid graduated with a Bachelor’s degree in Biotechnology from the University of Management and Technology, Pakistan, in 2019. Her Bachelor’s degree project was based on understanding the role of micro-RNA in neurodegenerative disorders. In 2020, she started a Master’s degree in Biological Sciences at University of Sialkot, Pakistan. Meanwhile, she was preparing to move to Spain. In 2021, she started her Master’s degree in Biomedical Research at Pompeu Fabra University, in Barcelona. For her Master’s thesis Nadia worked in the Pathophysiology of Rare Diseases group led by Dr. Federico Vicente Pallardo Calatayud at University of Valencia. Her thesis project was focused on understanding the role of ubiquibodies from camelids in the degradation of Huntingtin protein. During her stay in the laboratory, she gained experience in molecular laboratory techniques and cell culture. In April 2023, Nadia joined the P-CMR[C] in the Gene Regulation of Cell Identity lab led by Dr. Mireya Plass, as an Experimental Technician.